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Storage of Peptides: Complete Guide for Optimal Stability

Learn how to store peptides effectively to ensure optimal stability and potency. This guide covers essential practices for Retatrutide, Semaglutide, Tirzepatide, and more, including reconstitution tips and storage solutions.

26 januari 2026Redaktionen
Storage of Peptides: Complete Guide for Optimal Stability
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Why is storage so important?

Peptides are sensitive molecules. Incorrect storage can:

⚠️ Consequences of improper storage

  • Destroy effectiveness — The molecule breaks down
  • Reduce shelf life — Shorter usage period
  • Cause contamination — Bacterial growth
  • Provide unreliable results — Varying dose per administration

Basic rules for all peptides

🌡️ 1. Temperature

Condition Temperature Shelf Life
Unopened/lyophilized 2-8°C (refrigerator) 12-24 months
Reconstituted (mixed) 2-8°C (refrigerator) 28-30 days
Room temperature 15-25°C Max a few hours

☀️ 2. Light

Peptides are light-sensitive:

  • Store in original packaging or a dark container
  • Avoid direct sunlight
  • Fluorescent lighting can also affect them

💧 3. Moisture

Lyophilized peptides are extremely sensitive to moisture:

  • Do not open the packaging until ready to use
  • Store with silica gel packets if possible
  • Work quickly during reconstitution

Storage before mixing

Unopened lyophilized powder:

📦 Storage options

  • Best option: Refrigerator (2-8°C)
  • Acceptable: Freezer (-20°C) for long-term storage
  • Avoid: Room temperature longer than transport

💡 Tip

Allow the peptide to reach room temperature BEFORE opening to avoid condensation on the powder.

Storage after mixing

Reconstituted peptide requires extra caution:

✓ Use BAC water

Bacteriostatic water contains preservatives (benzyl alcohol) that prevent bacterial growth. With BAC water, the solution lasts 28-30 days.

Sterile water as an alternative

If using sterile water without preservatives:

  • Shelf life: Max 7-10 days
  • Requires stricter sterile technique
  • Less forgiving if contaminated

Specific peptides

Peptide Lyophilized Mixed Note
Semaglutide Refrigerator, 12+ months Refrigerator, 28 days Sensitive to agitation
Retatrutide Refrigerator or freezer Refrigerator, 28 days Same as Semaglutide
Tirzepatide Refrigerator Refrigerator, 28 days Relatively stable

📖 Learn more about Semaglutide →

Common mistakes to avoid

❌ Mistake 1: Storing in the refrigerator door

Problem: Temperature fluctuates the most here when opened.

Solution: Place at the back of the refrigerator.

❌ Mistake 2: Freezing reconstituted peptide

Problem: Ice crystals permanently destroy the molecular structure.

Solution: NEVER freeze mixed peptide.

❌ Mistake 3: Using an expired solution

Problem: Effectiveness decreases, risk of contamination.

Solution: Discard after 28-30 days, regardless of appearance.

❌ Mistake 4: Exposure to direct sunlight

Problem: UV radiation rapidly degrades the peptide.

Solution: Dark storage, original packaging.

Transport and travel

Traveling with peptides requires planning:

Short trip (1-2 days)

  • Cooler bag with ice packs
  • Avoid direct contact between ice and vial
  • Monitor temperature with a thermometer

Longer trips

  • Medical cooler with temperature control
  • Frozen ice packs that are replaced
  • Consider taking lyophilized and mixing on-site

How do you know if the peptide is damaged?

Signs of degradation:

🔍 Warning signs

  • Cloudy solution — Should be crystal clear
  • Particles or flakes — Signs of breakdown
  • Changed color — Should be colorless
  • Strange odor — May indicate contamination
  • Reduced effect — Clearest sign

💡 Rule

When in doubt — discard and use new. Your health is more important than the cost.

Practical tips

✓ Label your vials

Write on each vial:

  • What it is
  • Date of mixing
  • Concentration (mg/ml)
  • Expiration date

Organize the refrigerator

  • Have a dedicated drawer for peptides
  • Store away from food
  • Keep track of what is opened/unopened

Summary

✓ 6 golden rules

  1. Always refrigerate — 2-8°C is optimal
  2. Dark — Protect from light
  3. Never freeze mixed peptide
  4. 28 days max — after mixing
  5. Use BAC water — for best shelf life
  6. In doubt? Discard.

📖 Learn how to mix peptides correctly →

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